INDEPENDENT RESEARCH MONITOR
Registered, active, planned, completed and stopped studies are shown with their operational status and evidence level.
Registered, active, planned, completed and stopped studies are shown with their operational status and evidence level.
No records match these filters.
Phase 3 platform
Metformin + R/S alpha-lipoic acid
Active • Stage 1 analysis in progress
Evidence level: Human Phase 3 platform • Stage 1 efficacy decision pending
Next substantive checkpoint: Go/no-go decision for the initial arms around October 2026
Phase 2
Metformin • progressive MS
Active, not recruiting
Evidence level: Human Phase 2 • results pending
Next substantive checkpoint: Completion of follow-up and results after the primary study completion
Phase 2
Metformin • ages 55–75
Recruiting • NCT06463743
Evidence level: Human Phase 2 • results pending
Next substantive checkpoint: Safety plus MRS/MRI, myelin-water-fraction and neuroprotection or repair readouts
Phase 2
CXCR7 / ACKR3 antagonist • progressive MS
Recruiting
Evidence level: Human Phase 2 • results pending
Next substantive checkpoint: MRI, electrophysiological and biochemical remyelination endpoints at 48 weeks
Phase 1/2
Clemastine • chronic demyelination
Recruiting
Evidence level: Human Phase 1/2 • results pending
Next substantive checkpoint: Multiparametric MRI for changes in myelin • estimated completion 2027
Phase 2
Clemastine • acute optic neuritis
Recruiting
Evidence level: Human Phase 2 • results pending
Next substantive checkpoint: VEP and MRI remyelination evidence • estimated completion 2028
Phase 1/2
Clemastine • acute demyelinating lesions
Not yet recruiting • scheduled start 15 Sep 2026
Evidence level: Human Phase 1/2 • no results
Next substantive checkpoint: Recruitment opening and multiparametric MRI readouts for myelin repair
Phase 1/2
Ifenprodil • remyelination
Temporarily halted in CTIS
Evidence level: Human Phase 1/2 • temporarily halted
Next substantive checkpoint: Confirmation of restart or a new official status update
Pilot • device study
Vagus nerve stimulation • RRMS
Recruiting
Evidence level: Human pilot/device study • efficacy exploratory
Next substantive checkpoint: Safety and exploratory remyelination after the 48-week blinded period
Phase 2
Testosterone • RRMS
Ongoing / recruiting
Evidence level: Human Phase 2 • results pending
Next substantive checkpoint: MRI endpoints for remyelination and neuroprotection
Phase 1 • healthy volunteers
GPR17 antagonist
First-in-human programme authorised
Evidence level: Healthy-volunteer development • no MS efficacy data
Next substantive checkpoint: Safety, tolerability and PK before any efficacy study in people with MS
Phase 2 • planned
PAD2 inhibitor • progressive MS
FDA IND cleared • public trial registration not located
Evidence level: Human development milestone • no MS efficacy data
Next substantive checkpoint: Public Phase 2 registration, sites and recruitment opening
Phase 2a • completed
Metformin + clemastine
Positive biological VEP signal
Evidence level: Human Phase 2a • biological VEP signal; no short-term disability benefit shown
What comes next: Full peer-reviewed results and a larger confirmatory study
Phase 2 • completed
Bazedoxifene acetate
Primary and secondary remyelination endpoints not met
Evidence level: Human Phase 2 • null remyelination efficacy endpoints
Meaning: Generally well tolerated, but without a statistically significant efficacy signal
Phase 3 • terminated
Clemastine • INO in MS
Terminated after a futility no-go analysis
Evidence level: Human Phase 3 • terminated after futility analysis amid slow recruitment
Meaning: The decision followed slow recruitment and futility analysis; it is not by itself definitive proof that clemastine is ineffective
Phase 2 • completed
M1R antagonist
Efficacy endpoints not met
Evidence level: Human Phase 2 • efficacy endpoints not met
Meaning: Further development in MS remains uncertain
Early Phase 1 • completed
Metformin • PPMS/SPMS
Completed • results not yet published
Evidence level: Human early Phase 1 • completed; public results pending
What comes next: Public efficacy and safety readout from NCT05349474