Phase 3 platform
OCTOPUS: the first interim metformin/ALA analysis is scheduled for September 2026
The OCTOPUS Stage 1 analysis in progressive MS will assess metformin and alpha-lipoic acid. In addition to brain-atrophy MRI, the plan now includes EDSS, Timed 25-Foot Walk and 9-Hole Peg Test measures.
Practical availability: Research record — not presented as established care
What this means clinically
This is one of the nearest important milestones in progressive MS. Stage 1 may decide which arm continues, but it is not a final Phase 3 result.
Source quality: High for trial status • official academic update
University / investigatorOCTOPUS Trial / UCL ↗