:root{--ink:#2b241e;--ink-soft:#463a31;--muted:#6b5e53;--paper:#f6f1ea;--surface:#fffdf9;--surface-soft:#fff4e8;--line:#e7d8ca;--accent:#f58220;--accent-dark:#bf5700;--teal:#bf5700;--teal-soft:#fff0de;--yellow:#f58220;--max:1160px}

*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;background:var(--paper);color:var(--ink);font:16px/1.65 Inter,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif}
a{color:var(--teal);text-decoration-thickness:1px;text-underline-offset:3px}
a:hover{color:var(--accent-dark)}
button,input,select{font:inherit}
.wrap{width:min(calc(100% - 40px),var(--max));margin-inline:auto}
.narrow{max-width:820px}
.skip-link{position:absolute;left:-999px;top:10px;background:var(--ink);color:white;padding:8px 12px;z-index:20}
.skip-link:focus{left:10px}
.site-header{position:sticky;top:0;z-index:10;background:rgba(255,253,249,.94);border-bottom:1px solid var(--line);backdrop-filter:blur(10px)}
.header-inner{min-height:72px;display:flex;align-items:center;gap:24px}
.brand{display:inline-flex;align-items:center;gap:10px;color:var(--ink);font-weight:850;font-size:20px;letter-spacing:-.02em;text-decoration:none;white-space:nowrap}
.brand-mark{display:grid;place-items:center;width:38px;height:38px;border-radius:12px;background:var(--ink);color:#fffdf9;font-size:11px;letter-spacing:.08em}
.site-nav{display:flex;align-items:center;gap:4px;margin-left:auto}
.site-nav a{color:var(--ink-soft);padding:8px 10px;border-radius:8px;text-decoration:none;font-size:14px;font-weight:650}
.site-nav a:hover,.site-nav a.active{background:var(--teal-soft);color:var(--ink)}
.language-switch{font-size:12px;font-weight:850;letter-spacing:.08em;color:var(--accent-dark);text-decoration:none;border-left:1px solid var(--line);padding-left:18px}
.nav-toggle{display:none;margin-left:auto;border:1px solid var(--line);background:var(--surface);color:var(--ink);padding:8px 12px;border-radius:8px;font-weight:700}
.hero{border-bottom:1px solid var(--line);background:linear-gradient(135deg,#fbf7f2 0%,#f6f1ea 60%);padding:72px 0 64px}
.hero-grid{display:grid;grid-template-columns:minmax(0,1.45fr) minmax(240px,.55fr);gap:72px;align-items:end}
.eyebrow{margin:0 0 14px;color:var(--accent-dark);font-size:11px;font-weight:850;letter-spacing:.16em;text-transform:uppercase}
.hero h1,.program-hero h1{max-width:840px;margin:0;font-size:clamp(40px,6vw,74px);line-height:1.02;letter-spacing:-.055em}
.lede{max-width:720px;margin:25px 0 0;color:var(--ink-soft);font-size:19px;line-height:1.55}
.evidence-note{border-left:3px solid var(--accent);padding:4px 0 4px 22px}
.evidence-note span{display:block;color:var(--muted);font-size:12px;text-transform:uppercase;letter-spacing:.1em}
.evidence-note strong{display:block;margin-top:4px;font-size:20px}
.evidence-note p{margin:12px 0 0;color:var(--ink-soft);font-size:14px}
.content-section{padding:70px 0 10px}
.section-head{max-width:780px;margin-bottom:28px}
.section-head h2{margin:0;font-size:clamp(27px,4vw,42px);line-height:1.1;letter-spacing:-.035em}
.section-head p{margin:12px 0 0;color:var(--muted);font-size:17px}
.principle{margin-top:72px;padding:64px 0;background:var(--ink);color:#fbf7f2}
.principle h2{max-width:700px;margin:0;font-size:38px;line-height:1.1;letter-spacing:-.04em}
.principle p:not(.eyebrow){max-width:600px;color:#e7d8ca}
.button{display:inline-flex;margin-top:12px;background:var(--accent);color:#fffdf9;padding:11px 16px;border-radius:8px;text-decoration:none;font-weight:800}
.greece-section{background:#fbf7f2}
.greece-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px}
.greece-card{background:var(--surface);border:1px solid var(--line);border-radius:14px;padding:24px;box-shadow:0 5px 20px rgba(72,46,23,.04)}
.greece-card.featured{grid-column:span 2;border-color:#e5b889}
.greece-top{display:flex;justify-content:space-between;gap:14px;align-items:flex-start;color:var(--accent-dark);font-size:11px;font-weight:850;letter-spacing:.1em}
.greece-top time{color:var(--muted);letter-spacing:0;font-weight:600}
.greece-card h2{font-size:23px;line-height:1.25;letter-spacing:-.025em;margin:10px 0 13px}
.greece-card>p{color:var(--ink-soft)}
.card-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px}
.research-card{display:flex;flex-direction:column;min-width:0;background:var(--surface);border:1px solid var(--line);border-radius:12px;padding:20px;box-shadow:0 5px 18px rgba(72,46,23,.035)}
.research-card[hidden],.update-card[hidden]{display:none}
.research-card h2,.update-card h2{font-size:20px;line-height:1.25;letter-spacing:-.02em;margin:7px 0}
.research-card h2 a{color:var(--ink);text-decoration:none}
.research-card h2 a:hover{text-decoration:underline;text-decoration-color:var(--accent)}
.card-kicker{margin:0;color:var(--accent-dark);font-size:11px;font-weight:850;letter-spacing:.1em;text-transform:uppercase}
.candidate{margin:0;color:var(--muted);font-size:14px}
.status-copy{margin:14px 0 0;font-weight:750}
.evidence-copy,.next{margin:12px 0 0;color:var(--ink-soft);font-size:14px}
.card-footer{display:flex;justify-content:space-between;gap:10px;align-items:center;margin-top:auto;padding-top:20px}
.text-link{font-size:13px;font-weight:800}
.source-type{display:inline-block;border:1px solid var(--line);border-radius:100px;color:var(--muted);padding:2px 7px;font-size:10px;font-weight:750;white-space:nowrap}
.chips{display:flex;flex-wrap:wrap;gap:6px;margin:0 0 9px}
.chip{display:inline-flex;border-radius:100px;padding:3px 8px;font-size:10px;line-height:1.3;font-weight:800;letter-spacing:.02em}
.chip.evidence{background:var(--teal-soft);color:#7a3900}
.chip.status{background:#fff4e7;color:#b35e12}
.chip.direction{background:#fbf7f2;color:#6b5e53}
.chip.direction.positive{background:#fff4e7;color:#b35e12}
.chip.direction.negative{background:#fff3f3;color:#9e4b4b}
.chip.direction.null{background:#fbf7f2}
.filter-bar{display:grid;grid-template-columns:minmax(240px,1.5fr) repeat(2,minmax(170px,.7fr));gap:12px;margin:0 0 26px;padding:14px;background:var(--surface-soft);border:1px solid var(--line);border-radius:12px}
.filter-bar label span{display:block;margin-bottom:5px;color:var(--muted);font-size:11px;font-weight:800;letter-spacing:.04em}
.filter-bar input,.filter-bar select{width:100%;border:1px solid var(--line);border-radius:8px;background:#fffdf9;padding:9px 10px;color:var(--ink);outline:none}
.filter-bar input:focus,.filter-bar select:focus{border-color:var(--teal);box-shadow:0 0 0 3px rgba(245,130,32,.14)}
.empty-filter{padding:24px;border:1px dashed var(--line);border-radius:10px;color:var(--muted)}
.update-list{display:grid;gap:14px}
.update-card{display:grid;grid-template-columns:170px minmax(0,1fr);gap:24px;background:var(--surface);border:1px solid var(--line);border-radius:12px;padding:22px}
.update-meta time{display:block;color:var(--muted);font-size:13px;margin-bottom:12px}
.update-card h2{font-size:24px}
.update-card p{color:var(--ink-soft)}
.clinical-meaning{border-left:3px solid var(--yellow);padding:8px 0 8px 14px;margin:16px 0}
.clinical-meaning strong{font-size:12px;color:var(--ink);letter-spacing:.03em}
.clinical-meaning p{margin:4px 0 0;color:var(--ink-soft)}
.source-quality{font-size:13px}
.source-row{display:flex;flex-wrap:wrap;align-items:center;gap:8px;margin-top:13px;font-size:13px}
.source-row a{font-weight:700}
.method-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px}
.method-grid section{background:var(--surface);border:1px solid var(--line);border-radius:12px;padding:22px}
.method-grid h2{margin:0;font-size:20px;line-height:1.25}
.method-grid p{color:var(--ink-soft)}
.guide-glossary,.access-guide{margin-top:28px;background:var(--surface-soft);border:1px solid var(--line);border-radius:12px;padding:24px}
.guide-glossary h2,.access-guide h2{margin:0;font-size:24px;line-height:1.2}
.guide-glossary>p,.access-guide>p{color:var(--ink-soft)}
.glossary{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:0 24px;margin:18px 0 0}
.glossary div{padding:14px 0;border-top:1px solid var(--line)}
.glossary dt{font-weight:850}
.glossary dd{margin:4px 0 0;color:var(--ink-soft)}
.access-guide ol{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px;margin:22px 0 0;padding:0;list-style:none}
.access-guide li{display:grid;gap:5px;color:var(--ink-soft)}
.access-guide li strong{color:var(--ink)}
.program-hero{background:var(--ink);color:#fbf7f2;padding:56px 0}
.program-hero .back-link{display:inline-block;margin-bottom:26px;color:#e7d8ca;font-size:14px}
.program-hero .eyebrow{color:#f58220}
.program-hero .lede{color:#e7d8ca}
.program-hero .chip.evidence{background:#7a3900;color:#fff0de}
.program-hero .chip.status{background:#9e4b4b;color:#fff0de}
.fact-list{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:0;border-top:1px solid var(--line);border-bottom:1px solid var(--line);margin:0 0 26px}
.fact-list div{padding:14px 16px 14px 0;border-bottom:1px solid var(--line)}
.fact-list div:nth-last-child(-n+2){border-bottom:0}
.fact-list dt{color:var(--muted);font-size:11px;font-weight:850;letter-spacing:.08em;text-transform:uppercase}
.fact-list dd{margin:3px 0 0;color:var(--ink-soft)}
.source-panel{display:flex;flex-wrap:wrap;gap:10px;align-items:center;margin-top:24px;padding:16px;background:var(--surface-soft);border-radius:10px;font-size:13px}
.source-panel span:last-child{margin-left:auto;color:var(--muted)}
.site-footer{margin-top:90px;background:var(--ink);color:#e7d8ca;padding:42px 0}
.footer-grid{display:flex;justify-content:space-between;gap:30px}
.footer-grid strong{font-size:19px;color:#fffdf9}
.footer-grid p{margin:5px 0;color:#d9c2ad;font-size:13px}
.engine-note{font-size:12px!important}
.latest-section .update-list{max-width:980px}
.site-footer a{color:#f58220}

@media(max-width:980px){.site-nav{gap:0}
.site-nav a{padding-inline:7px}
.card-grid{grid-template-columns:repeat(2,minmax(0,1fr))}
.hero-grid{gap:38px}
}

@media(max-width:760px){.wrap{width:min(calc(100% - 28px),var(--max))}
.header-inner{min-height:64px;flex-wrap:wrap;gap:12px}
.nav-toggle{display:block}
.site-nav{display:none;order:4;width:100%;margin:0;padding:8px 0 14px;border-top:1px solid var(--line);flex-wrap:wrap}
.site-nav.open{display:flex}
.site-nav a{padding:8px 9px}
.language-switch{margin-left:0;border-left:0;padding-left:6px}
.hero{padding:52px 0 44px}
.hero-grid{grid-template-columns:1fr;gap:30px}
.hero h1,.program-hero h1{font-size:clamp(38px,13vw,58px)}
.lede{font-size:17px}
.content-section{padding-top:52px}
.greece-grid,.card-grid,.method-grid{grid-template-columns:1fr}
.greece-card.featured{grid-column:auto}
.filter-bar{grid-template-columns:1fr}
.update-card{grid-template-columns:1fr;gap:8px}
.update-meta .chips{margin-bottom:0}
.fact-list{grid-template-columns:1fr}
.fact-list div:nth-last-child(-n+2){border-bottom:1px solid var(--line)}
.fact-list div:last-child{border-bottom:0}
.source-panel span:last-child{margin-left:0;width:100%}
.footer-grid{display:block}
.footer-grid>div+div{margin-top:18px}
.glossary,.access-guide ol{grid-template-columns:1fr}
}